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Jeffrey I. Gordon (born 1947) is a biologist and the Dr. Robert J. Glaser Distinguished University Professor and Director of the Center for Genome Sciences and Systems Biology at Washington University in St. Louis.〔()〕 He is internationally known for his research on gastrointestinal development and how gut microbial communities affect normal intestinal function, shape various aspects of human physiology including our nutritional status, and affect predisposition to diseases.〔(Washington University News )〕 He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences and the Institute of Medicine of the National Academies. ==Education and early career== Gordon received his bachelor’s degree in Biology at 1969 at Oberlin College in Ohio. Over the next four years, Gordon received his medical training at the University of Chicago and graduated with honors in 1973. After two years as intern and junior assistant resident in Medicine at Barnes Hospital, St Louis, Gordon joined the Laboratory of Biochemistry at the National Cancer Institute as a Research Associate in 1975. He returned to Barnes Hospital in 1978 to become Senior Assistant Resident and then Chief Medical Resident at Washington University Medical Service. In 1981 he completed a fellowship in medicine (Gastroenterology) at Washington University School of Medicine. In the following years, Gordon rose quickly through the academic ranks at Washington University: Asst. Prof. (1981–1984); Assoc. Prof. (1985–1987); Prof. (1987–1991) of Medicine and Biological Chemistry. In 1991, he became head of the Dept. Molecular Biology & Pharmacology (1991–2004). Gordon is currently the Director of the Center for Genome Sciences (2004–present) at Washington University. Gordon’s early career focused on the development of cell lineages within the gastrointestinal tract. His laboratory initially combined the use of transgenic mouse models and biochemical approaches to elucidate the mechanisms of gut epithelial development along the duodenal-colonic and crypt-villus axes. Early studies also provided important insight into biochemical properties of lipid handling and transport in the digestive system. Dr. Gordon and colleagues later combined laser capture microdissection, and functional genomics to characterize specified cell populations within the gastrointestinal tract, including multipotent stem cells. Gordon played a pivotal role in the study of protein N-myristoylation, a co-translational modification by which a myristoyl group is covalently attached to an N-terminal glycine residue of a nascent polypeptide. Gordon and his colleagues were instrumental in characterizing the mechanism by which N-myristoyltransferase (the enzyme that catalyzes the myristoylation reaction) selects its substrates and its catalytic mechanism.〔Kresge et al., N-Myristoyltransferase Substrate Selection and Catalysis: the Work of Jeffrey I. Gordon. J. Biol. Chem. 2008〕 Gordon’s group published a series of elegant studies that describe the ability of components of the commensal microbiota to induce specific responses in the host intestinal epithelium. One of these responses, the induction of intestinal cell surface fucose residues, is elicited by a prominent human intestinal symbiont,'' Bacteroides thetaiotaomicron'', which can harvest and use the host fucose as a carbon and energy source.〔Bry et al., A model of host-microbial interactions in an open mammalian ecosystem. Science. 1996〕 Gordon’s group published a seminal study in which functional genomics were used to document the genome-wide intestinal epithelial response to microbial colonization of the gastrointestinal tract.〔Hooper et al., Molecular analysis of commensal host-microbial relationships in the intestine. Science. 2001〕 Dr. Gordon’s laboratory has investigated epithelial cell interaction with human-associated pathogens, including uropathogenic ''Escherichia coli'', ''Helicobacter pylori'', and ''Listeria monocytogenes''. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Jeffrey I. Gordon」の詳細全文を読む スポンサード リンク
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